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Because it occupies a substantial bluff rising from the Mississippi river bank, the area is a natural location for settlement. The Memphis area was first settled by the Mississippian Culture and then by the Chickasaw Indian tribe. European exploration came years later, with Spanish explorer Hernando de Soto and French explorers led by René Robert Cavelier, Sieur de La Salle.The land comprising present-day Memphis remained in a largely unorganized territory throughout most of the 18th century. By 1796, the community was the westernmost point of the newly admitted state of Tennessee, located in the Southeast America.

The city of Memphis is located in southwestern Tennessee and sits on the eastern bank of the Mississippi River. It is the regional hub for a tri-state area of Arkansas, Mississippi and Tennessee. Interstate 40 (I-40) enters the city from the northeast, and loops above the central part of the city, exiting across the Mississippi River and travelling to the west. Interstate 55 approaches the city from the south and connects with Interstate 240, which completes the loop around central Memphis with I-40, and also leaves to the west.